| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Tyler Stephenson | C | Cin | 28 | |
| Matt Mervis | 1B | Mia | 27 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Matt McLain | 2B | Cin | 25 | |
| Carlos Correa | SS | Min | 30 | |
| Gunnar Henderson | SS | Bal | 23 | |
| Trea Turner | SS | Phi | 31 | |
| Alec Bohm | 3B | Phi | 28 | |
| Josh Jung | 3B | Tex | 27 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Ben Williamson | 3B | Sea | N/A | |
| Ronald Acuna Jr. | OF | Atl | 27 | March 25, 2025:10 Day IL |
| Lawrence Butler | OF | Oak | 24 | |
| Corbin Carroll | OF | Ari | 24 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Lars Nootbaar | OF | StL | 27 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Jordan Walker | OF | StL | 22 | |
| Shane Baz | SP | TB | 25 | |
| Jose Berrios | SP | Tor | 30 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Max Meyer | SP | Mia | 26 | |
| Drew Rasmussen | SP | TB | 29 | |
| Carlos Rodon | SP | NYA | 32 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| JP Sears | SP | Oak | 29 | |
| Shane Smith | SP | ChA | N/A | |
| Camilo Doval | RP | SF | 27 | |
| Luke Jackson | RP | Tex | 33 | |
| Trevor Megill | RP | Mil | 31 | |
| Will Vest | RP | Det | 29 |