| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Agustin Ramirez | C | Mia | 23 | |
| Austin Wells | C | NYA | 25 | |
| Pete Alonso | 1B | NYN | 30 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Marcelo Mayer | SS | Bos | 22 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jacob Wilson | SS | Oak | 23 | |
| Josh Jung | 3B | Tex | 27 | |
| Connor Norby | 3B | Mia | 24 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Roman Anthony | OF | Bos | 20 | |
| Corbin Carroll | OF | Ari | 24 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Chandler Simpson | OF | TB | 24 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Garrett Crochet | SP | Bos | 25 | |
| Tony Gonsolin | SP | LAD | 30 | |
| Gunnar Hoglund | SP | Oak | 25 | |
| Clay Holmes | SP | NYN | 32 | |
| Cade Horton | SP | ChN | 23 | |
| Jackson Jobe | SP | Det | 22 | |
| Jack Leiter | SP | Tex | N/A | |
| Ryan Pepiot | SP | TB | 27 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| José Alvarado | RP | Phi | 29 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Edwin Diaz | RP | NYN | 31 |