| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Ryan Jeffers | C | Min | 27 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Freddie Freeman | 1B | LAD | 35 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Marcus Semien | 2B | Tex | 34 | |
| Gleyber Torres | 2B | Det | 28 | |
| Jordan Lawlar | SS | Ari | 22 | |
| Dansby Swanson | SS | ChN | 31 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Josh Jung | 3B | Tex | 27 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Isaac Paredes | 3B | Hou | 26 | |
| Roman Anthony | OF | Bos | 20 | |
| Jackson Chourio | OF | Mil | 21 | |
| Walker Jenkins | OF | Min | 20 | |
| Max Kepler | OF | Phi | 32 | |
| Wyatt Langford | OF | Tex | 23 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Kyle Tucker | OF | ChN | 28 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Shane Baz | SP | TB | 25 | |
| Bubba Chandler | SP | Pit | N/A | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Kevin Gausman | SP | Tor | 34 | |
| Tanner Houck | SP | Bos | 28 | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Michael King | SP | SD | 29 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Jose Quintana | SP | Mil | 36 | |
| Gavin Williams | SP | Cle | 25 | |
| Kyle Finnegan | RP | Was | 33 | |
| Andres Munoz | RP | Sea | 26 |