| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | August 14, 2025:10 Day IL |
| Drake Baldwin | C | Atl | 24 | |
| Ryan Jeffers | C | Min | 28 | September 07, 2025:7 Day IL |
| Tyler Stephenson | C | Cin | 29 | |
| Bryce Harper | 1B | Phi | 32 | |
| Ryan O'Hearn | 1B (OF) | SD | 32 | |
| Nick Gonzales | 2B | Pit | 26 | |
| Gleyber Torres | 2B | Det | 28 | |
| Willy Adames | SS | SF | 30 | |
| Javier Baez | SS (2B,3B,OF) | Det | 32 | |
| Alec Bohm | 3B (1B) | Phi | 29 | September 08, 2025:10 Day IL |
| Maikel Garcia | 3B (2B,SS,OF) | KC | 25 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Colton Cowser | OF | Bal | 25 | |
| Jarren Duran | OF | Bos | 29 | |
| Aaron Judge | OF | NYA | 33 | |
| Josh Lowe | OF | TB | 27 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Brent Rooker | OF | Oak | 30 | |
| Anthony Santander | OF | Tor | 30 | May 30, 2025:10 Day IL |
| Mike Trout | OF | LAA | 34 | |
| Luis Castillo | SP | Sea | 32 | |
| Gerrit Cole | SP | NYA | 35 | March 22, 2025:60 Day IL |
| Yusei Kikuchi | SP | LAA | 34 | |
| George Kirby | SP | Sea | 27 | |
| Jesus Luzardo | SP | Phi | 27 | |
| David Peterson | SP | NYN | 30 | |
| Carlos Rodon | SP | NYA | 32 | |
| Trevor Rogers | SP | Bal | 27 | |
| Joe Ryan | SP | Min | 29 | |
| Chris Sale | SP | Atl | 36 | |
| Max Scherzer | SP | Tor | 41 | |
| Kodai Senga | SP | NYN | 32 | |
| Justin Verlander | SP | SF | 42 |