| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Carson Kelly | C | ChN | 30 | |
| Triston Casas | 1B | Bos | 25 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Spencer Torkelson | 1B | Det | 25 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Matt McLain | 2B | Cin | 25 | |
| Bo Bichette | SS | Tor | 27 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Masyn Winn | SS | StL | 23 | |
| Junior Caminero | 3B | TB | 21 | |
| Matt Shaw | 3B | ChN | 23 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Roman Anthony | OF | Bos | 20 | |
| Jackson Chourio | OF | Mil | 21 | |
| Oneil Cruz | OF | Pit | 26 | |
| Walker Jenkins | OF | Min | 20 | |
| Wyatt Langford | OF | Tex | 23 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Andy Pages | OF | LAD | 24 | |
| Jordan Walker | OF | StL | 22 | |
| Shane Baz | SP | TB | 25 | |
| Jack Flaherty | SP | Det | 29 | |
| MacKenzie Gore | SP | Was | 26 | |
| Dustin May | SP | LAD | 27 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Jose Quintana | SP | Mil | 36 | |
| Kodai Senga | SP | NYN | 32 | |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Michael Wacha | SP | KC | 33 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Carlos Estevez | RP | KC | 32 | |
| Trevor Megill | RP | Mil | 31 |