| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Bo Naylor | C | Cle | 25 | |
| Will Smith | C | LAD | 30 | |
| Bryce Harper | 1B | Phi | 32 | |
| Rowdy Tellez | 1B | Sea | 30 | |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Brooks Lee | 2B (3B) | Min | 24 | |
| Ketel Marte | 2B | Ari | 31 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Anthony Volpe | SS | NYA | 24 | |
| Brooks Baldwin | 3B (2B,SS,OF) | ChA | N/A | |
| Jose Ramirez | 3B | Cle | 32 | |
| JJ Bleday | OF | Oak | 27 | |
| Aaron Judge | OF | NYA | 33 | |
| Brent Rooker | OF | Oak | 30 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Jorge Soler | OF | LAA | 32 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Taylor Ward | OF | LAA | 31 | |
| Marcell Ozuna | DH | Atl | 34 | |
| Chris Bassitt | SP | Tor | 36 | |
| Brayan Bello | SP | Bos | 25 | |
| Tanner Bibee | SP | Cle | 26 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Kevin Gausman | SP | Tor | 34 | |
| Merrill Kelly | SP | Ari | 36 | |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| Tarik Skubal | SP | Det | 28 | |
| Zack Wheeler | SP | Phi | 34 | |
| Gavin Williams | SP | Cle | 25 | |
| Felix Bautista | RP | Bal | 29 | |
| Tommy Kahnle | RP | Det | 35 | |
| Shelby Miller | RP | Ari | 34 |