| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Carson Kelly | C | ChN | 30 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Rhys Hoskins | 1B | Mil | 32 | |
| Christian Walker | 1B | Hou | 34 | |
| Luis Garcia | 2B | Was | 24 | |
| Matt McLain | 2B | Cin | 25 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Caleb Durbin | 3B | Mil | 25 | |
| Alex Freeland | 3B | LAD | N/A | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Noelvi Marte | 3B | Cin | 23 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Riley Greene | OF | Det | 24 | |
| Lars Nootbaar | OF | StL | 27 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Emmanuel Rodriguez | OF | Min | N/A | |
| Victor Scott | OF | StL | 24 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Colby Thomas | OF | Oak | 24 | |
| Taj Bradley | SP | TB | 24 | |
| Chase Dollander | SP | Col | N/A | |
| Jackson Jobe | SP | Det | 22 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Matthew Liberatore | SP | StL | 25 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Cole Ragans | SP | KC | 27 | |
| Roki Sasaki | SP | LAD | 23 | |
| Brady Singer | SP | Cin | 28 | |
| Tanner Scott | RP | LAD | 30 | |
| Ryan Walker | RP | SF | N/A |