| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Pedro Pages | C | StL | 26 | |
| Will Smith | C | LAD | 30 | |
| Michael Busch | 1B | ChN | 27 | |
| Deyvison De Los Santos | 1B | Mia | 21 | |
| Michael Toglia | 1B | Col | 26 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Andrés Gimenez | 2B | Tor | 26 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Adael Amador | SS (2B) | Col | N/A | |
| Bo Bichette | SS | Tor | 27 | |
| Manny Machado | 3B | SD | 32 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Matt Shaw | 3B | ChN | 23 | |
| Brenton Doyle | OF | Col | 26 | |
| TJ Friedl | OF | Cin | 29 | |
| Michael Harris II | OF | Atl | 24 | |
| Justyn-Henry Malloy | OF | Det | 25 | |
| Kameron Misner | OF | TB | N/A | |
| Brent Rooker | OF | Oak | 30 | |
| Daulton Varsho | OF | Tor | 28 | |
| Brayan Bello | SP | Bos | 25 | |
| Corbin Burnes | SP | Ari | 30 | |
| Zac Gallen | SP | Ari | 29 | |
| Jake Irvin | SP | Was | 28 | |
| Mitchell Parker | SP | Was | 25 | |
| David Peterson | SP | NYN | 29 | |
| Landen Roupp | SP | SF | N/A | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Logan Webb | SP | SF | 28 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Bryan Woo | SP | Sea | 25 | |
| Ryan Helsley | RP | StL | 30 |