| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Austin Wells | C | NYA | 25 | |
| Luis Arraez | 1B | SD | 28 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Brice Turang | 2B | Mil | 25 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Jacob Wilson | SS | Oak | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Wilyer Abreu | OF | Bos | 25 | |
| Dylan Crews | OF | Was | 23 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Walker Jenkins | OF | Min | 20 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Garrett Crochet | SP | Bos | 25 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Tony Gonsolin | SP | LAD | 30 | |
| Gunnar Hoglund | SP | Oak | 25 | |
| Clay Holmes | SP | NYN | 32 | |
| Jackson Jobe | SP | Det | 22 | |
| Jack Leiter | SP | Tex | N/A | |
| Cole Ragans | SP | KC | 27 | |
| Landen Roupp | SP | SF | N/A | |
| Roki Sasaki | SP | LAD | 23 | |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Gavin Williams | SP | Cle | 25 | |
| David Bednar | RP | Pit | 30 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Edwin Diaz | RP | NYN | 31 | |
| Luke Jackson | RP | Tex | 33 |