| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Dillon Dingler | C | Det | N/A | |
| Logan O'Hoppe | C | LAA | 25 | |
| Ethan Salas | C | SD | 18 | |
| Michael Busch | 1B | ChN | 27 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Francisco Lindor | SS | NYN | 31 | |
| Colson Montgomery | SS | ChA | 23 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Mark Vientos | 3B | NYN | 25 | |
| Ben Williamson | 3B | Sea | N/A | |
| JJ Bleday | OF | Oak | 27 | |
| Aaron Judge | OF | NYA | 33 | |
| Kameron Misner | OF | TB | N/A | |
| George Springer | OF | Tor | 35 | |
| James Wood | OF | Was | 22 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Sonny Gray | SP | StL | 35 | |
| Andrew Heaney | SP | Pit | 33 | |
| Jake Irvin | SP | Was | 28 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Seth Lugo | SP | KC | 35 | |
| Davis Martin | SP | ChA | 28 | |
| Michael McGreevy | SP | StL | 24 | |
| Andrew Painter | SP | Phi | N/A | |
| Andre Pallante | SP | StL | 26 | |
| JP Sears | SP | Oak | 29 | |
| Logan Webb | SP | SF | 28 | |
| Camilo Doval | RP | SF | 27 | |
| Logan Evans | RP | Sea | N/A |