| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Keibert Ruiz | C | Was | 26 | |
| Luis Arraez | 1B | SD | 28 | |
| Jac Caglianone | 1B | KC | 22 | |
| Deyvison De Los Santos | 1B | Mia | 21 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Michael Toglia | 1B | Col | 26 | |
| Luisangel Acuna | 2B | NYN | 23 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| Matt McLain | 2B | Cin | 25 | |
| Christian Moore | 2B | LAA | 22 | |
| Xander Bogaerts | SS | SD | 32 | |
| J.P. Crawford | SS | Sea | 30 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Carson Williams | SS | TB | 21 | |
| Junior Caminero | 3B | TB | 21 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Matt Shaw | 3B | ChN | 23 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Randy Arozarena | OF | Sea | 30 | |
| Corbin Carroll | OF | Ari | 24 | |
| Michael Harris II | OF | Atl | 24 | |
| Chandler Simpson | OF | TB | 24 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Brayan Bello | SP | Bos | 25 | |
| Kris Bubic | SP | KC | 27 | |
| Luis Castillo | SP | Sea | 32 | |
| Bailey Ober | SP | Min | 29 | |
| Freddy Peralta | SP | Mil | 28 | |
| Robbie Ray | SP | SF | 33 | |
| Joe Ryan | SP | Min | 28 | |
| Chris Sale | SP | Atl | 36 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Andres Munoz | RP | Sea | 26 |