| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Shea Langeliers | C | Oak | 27 | |
| Yandy Diaz | 1B | TB | 33 | |
| Ben Rice | 1B | NYA | 26 | |
| Rob Refsnyder | 2B (OF) | Bos | 34 | |
| Luis Rengifo | 2B (3B) | LAA | 28 | |
| Zach Neto | SS | LAA | 24 | |
| Trevor Story | SS | Bos | 32 | |
| Isaac Paredes | 3B | Hou | 26 | |
| Austin Riley | 3B | Atl | 28 | |
| Kerry Carpenter | OF | Det | 27 | |
| Tommy Edman | OF (2B) | LAD | 29 | May 03, 2025:10 Day IL |
| Wyatt Langford | OF | Tex | 23 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Brent Rooker | OF | Oak | 30 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Victor Scott | OF | StL | 24 | |
| Kyle Stowers | OF | Mia | 27 | |
| Mike Yastrzemski | OF | SF | 34 | |
| Andrew Abbott | SP | Cin | 25 | |
| Jose Berrios | SP | Tor | 30 | |
| Dylan Cease | SP | SD | 29 | |
| Grant Holman | SP (RP) | Oak | N/A | |
| Nick Lodolo | SP | Cin | 27 | |
| Tyler Mahle | SP | Tex | 30 | |
| David Peterson | SP | NYN | 29 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Carlos Estevez | RP | KC | 32 | |
| Josh Hader | RP | Hou | 31 | |
| Ryan Helsley | RP | StL | 30 |