| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Carson Kelly | C | ChN | 30 | |
| Pedro Pages | C | StL | 26 | |
| Yandy Diaz | 1B | TB | 33 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Freddie Freeman | 1B | LAD | 35 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Ben Rice | 1B | NYA | 26 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Matt McLain | 2B | Cin | 25 | |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Carlos Correa | SS | Min | 30 | |
| Jeremy Pena | SS | Hou | 27 | |
| Rafael Devers | 3B | Bos | 28 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Coby Mayo | 3B | Bal | 23 | |
| Evan Carter | OF | Tex | 22 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Brenton Doyle | OF | Col | 26 | |
| Trent Grisham | OF | NYA | 28 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Andrew Abbott | SP | Cin | 25 | |
| Jacob deGrom | SP | Tex | 36 | |
| Max Fried | SP | NYA | 31 | |
| Ryan Gusto | SP (RP) | Hou | N/A | |
| Zebby Matthews | SP | Min | N/A | |
| Drew Rasmussen | SP | TB | 29 | |
| Kumar Rocker | SP | Tex | N/A | April 25, 2025:15 Day IL |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Kodai Senga | SP | NYN | 32 | |
| Bryan Woo | SP | Sea | 25 | |
| Carlos Estevez | RP | KC | 32 | |
| Raisel Iglesias | RP | Atl | 35 |