| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Sean Murphy | C | Atl | 30 | |
| Pete Alonso | 1B | NYN | 30 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Bryce Eldridge | 1B | SF | 20 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Marcus Semien | 2B | Tex | 34 | |
| Xavier Edwards | SS | Mia | 25 | |
| Dansby Swanson | SS | ChN | 31 | |
| Manny Machado | 3B | SD | 32 | |
| Ben Williamson | 3B | Sea | N/A | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Brenton Doyle | OF | Col | 26 | |
| Adolis Garcia | OF | Tex | 32 | |
| Kameron Misner | OF | TB | N/A | |
| Julio Rodriguez | OF | Sea | 24 | |
| Alex Verdugo | OF | Atl | 28 | |
| Matt Wallner | OF | Min | 27 | April 17, 2025:10 Day IL |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Jacob deGrom | SP | Tex | 36 | |
| Lucas Giolito | SP | Bos | 30 | |
| MacKenzie Gore | SP | Was | 26 | |
| Shota Imanaga | SP | ChN | 31 | |
| Jackson Jobe | SP | Det | 22 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Freddy Peralta | SP | Mil | 28 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Shane Smith | SP | ChA | N/A | |
| Gavin Williams | SP | Cle | 25 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Pete Fairbanks | RP | TB | 31 | |
| Trevor Megill | RP | Mil | 31 |