| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Cal Raleigh | C | Sea | 28 | |
| Michael Busch | 1B | ChN | 27 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Jordan Lawlar | SS | Ari | 22 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Zach Neto | SS | LAA | 24 | |
| Trevor Story | SS | Bos | 32 | |
| Junior Caminero | 3B | TB | 21 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Chase Meidroth | 3B (2B,SS) | ChA | N/A | |
| Isaac Paredes | 3B | Hou | 26 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Dylan Crews | OF | Was | 23 | |
| Wyatt Langford | OF | Tex | 23 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Daulton Varsho | OF | Tor | 28 | |
| James Wood | OF | Was | 22 | |
| Griffin Canning | SP | NYN | 28 | |
| Tyler Mahle | SP | Tex | 30 | |
| Casey Mize | SP | Det | 28 | |
| Mitchell Parker | SP | Was | 25 | |
| Drew Rasmussen | SP | TB | 29 | |
| Roki Sasaki | SP | LAD | 23 | |
| Luis Severino | SP | Oak | 31 | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Ryan Helsley | RP | StL | 30 | |
| Emilio Pagan | RP | Cin | 33 | |
| Devin Williams | RP | NYA | 30 |