| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ryan Jeffers | C | Min | 27 | |
| Agustin Ramirez | C | Mia | 23 | |
| Will Smith | C | LAD | 30 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Christian Walker | 1B | Hou | 34 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Bryson Stott | 2B | Phi | 27 | |
| Mookie Betts | SS | LAD | 32 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Trea Turner | SS | Phi | 31 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Connor Norby | 3B | Mia | 24 | |
| Cody Bellinger | OF | NYA | 29 | |
| Steven Kwan | OF | Cle | 27 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Andy Pages | OF | LAD | 24 | |
| Alek Thomas | OF | Ari | 25 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Jose Berrios | SP | Tor | 30 | |
| Kris Bubic | SP | KC | 27 | |
| Zac Gallen | SP | Ari | 29 | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Tony Gonsolin | SP | LAD | 30 | |
| Andrew Heaney | SP | Pit | 33 | |
| Seth Lugo | SP | KC | 35 | |
| Davis Martin | SP | ChA | 28 | |
| David Peterson | SP | NYN | 29 | |
| Jameson Taillon | SP | ChN | 33 | |
| José Alvarado | RP | Phi | 29 | |
| Tanner Scott | RP | LAD | 30 | |
| Robert Suarez | RP | SD | 34 |