| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Danny Jansen | C | Tor | 29 | |
| Triston Casas | 1B | Bos | 24 | April 21, 2024:60 Day IL- |
| Anthony Rizzo | 1B | NYA | 34 | |
| Zack Gelof | 2B | Oak | 24 | April 25, 2024:10 Day IL- |
| Matt McLain | 2B | Cin | 24 | March 28, 2024:10 Day IL- |
| Rob Refsnyder | 2B (OF) | Bos | 33 | |
| Jordan Westburg | 2B (3B) | Bal | 25 | |
| Jackson Merrill | SS (OF) | SD | 21 | |
| Anthony Volpe | SS | NYA | 23 | |
| Josh Jung | 3B | Tex | 26 | April 08, 2024:60 Day IL-Fractured right wrist |
| Noelvi Marte | 3B | Cin | 22 | |
| Josh Smith | 3B (SS) | Tex | 26 | |
| Jordan Beck | OF | Col | 23 | |
| Willie Calhoun | OF | LAA | 29 | |
| Corbin Carroll | OF | Ari | 23 | |
| Hunter Goodman | OF | Col | 24 | |
| Riley Greene | OF | Det | 23 | |
| Mitch Haniger | OF | Sea | 33 | |
| Eloy Jimenez | OF | ChA | 27 | |
| Nolan Jones | OF | Col | 26 | April 30, 2024:10 Day IL- |
| Spencer Jones | OF | NYA | 22 | |
| Heston Kjerstad | OF | Bal | 25 | |
| Tyler O'Neill | OF | Bos | 28 | |
| Andy Pages | OF | LAD | 23 | |
| Jordan Walker | OF | StL | 21 | |
| George Kirby | SP | Sea | 26 | |
| Nick Lodolo | SP | Cin | 26 | |
| Grayson Rodriguez | SP | Bal | 24 | May 01, 2024:15 Day IL-Shoulder Injury |
| Cristopher Sanchez | SP | Phi | 27 | |
| Gavin Stone | SP | LAD | 25 | |
| Justin Verlander | SP | Hou | 41 | |
| Jhoan Duran | RP | Min | 26 | |
| Mason Miller | RP | Oak | 25 | |
| Andres Munoz | RP | Sea | 25 |