| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Dillon Dingler | C | Det | N/A | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Gabriel Moreno | C | Ari | 25 | |
| Dalton Rushing | C | LAD | 24 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Wilmer Flores | 2B | SF | 33 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Brandon Lowe | 2B | TB | 30 | |
| Willy Adames | SS | SF | 29 | |
| J.P. Crawford | SS | Sea | 30 | |
| Rafael Devers | 3B | Bos | 28 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Ronald Acuna Jr. | OF | Atl | 27 | March 25, 2025:10 Day IL |
| Yordan Alvarez | OF | Hou | 27 | |
| Jordan Beck | OF | Col | 24 | |
| Christopher Morel | OF | TB | 25 | |
| Juan Soto | OF | NYN | 26 | |
| Ronel Blanco | SP | Hou | 31 | |
| Matt Boyd | SP | ChN | 34 | |
| Bubba Chandler | SP | Pit | N/A | |
| Hunter Dobbins | SP | Bos | N/A | |
| Max Fried | SP | NYA | 31 | |
| Hunter Greene | SP | Cin | 25 | |
| Jacob Misiorowski | SP | Mil | N/A | |
| Jose Quintana | SP | Mil | 36 | |
| JP Sears | SP | Oak | 29 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Framber Valdez | SP | Hou | 31 | |
| Logan Webb | SP | SF | 28 | |
| Jhoan Duran | RP | Min | 27 | |
| Kyle Finnegan | RP | Was | 33 | |
| Raisel Iglesias | RP | Atl | 35 |