| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Keibert Ruiz | C | Was | 26 | |
| Deyvison De Los Santos | 1B | Mia | 21 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Matt Mervis | 1B | Mia | 27 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Brice Turang | 2B | Mil | 25 | |
| Carlos Correa | SS | Min | 30 | |
| Paul DeJong | SS (3B) | Was | 31 | April 16, 2025:10 Day IL-Fractured nose |
| Zach Dezenzo | 3B (OF) | Hou | N/A | |
| Coby Mayo | 3B | Bal | 23 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Mark Vientos | 3B | NYN | 25 | |
| Evan Carter | OF | Tex | 22 | |
| Jerar Encarnación | OF | SF | 27 | March 26, 2025:60 Day IL |
| Hunter Goodman | OF (C) | Col | 25 | |
| Ian Happ | OF | ChN | 30 | |
| Austin Hays | OF | Cin | 29 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Victor Scott | OF | StL | 24 | |
| Kyle Stowers | OF | Mia | 27 | |
| Colby Thomas | OF | Oak | 24 | |
| Christian Yelich | OF | Mil | 33 | |
| Andrew Abbott | SP | Cin | 25 | |
| Kevin Gausman | SP | Tor | 34 | |
| Grant Holmes | SP | Atl | N/A | |
| Zebby Matthews | SP | Min | N/A | |
| Bryce Miller | SP | Sea | 26 | |
| Luis Ortiz | SP | Cle | 26 | |
| Andrew Painter | SP | Phi | N/A | |
| José Soriano | SP | LAA | 26 | |
| Ryan Weathers | SP | Mia | 25 | March 27, 2025:15 Day IL |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Kenley Jansen | RP | LAA | 37 |