| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Austin Wells | C | NYA | 25 | |
| Pete Alonso | 1B | NYN | 30 | |
| Jac Caglianone | 1B | KC | 22 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Luisangel Acuna | 2B | NYN | 23 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Kyren Paris | SS (2B,OF) | LAA | 23 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jacob Wilson | SS | Oak | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Michael Conforto | OF | LAD | 32 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Chandler Simpson | OF | TB | 24 | |
| Juan Soto | OF | NYN | 26 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Garrett Crochet | SP | Bos | 25 | |
| Tony Gonsolin | SP | LAD | 30 | |
| Gunnar Hoglund | SP | Oak | 25 | |
| Cade Horton | SP | ChN | 23 | |
| Jackson Jobe | SP | Det | 22 | |
| Jack Leiter | SP | Tex | N/A | |
| Dustin May | SP | LAD | 27 | |
| Ryan Pepiot | SP | TB | 27 | |
| Cole Ragans | SP | KC | 27 | |
| Landen Roupp | SP | SF | N/A | |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Edwin Diaz | RP | NYN | 31 | |
| AJ Puk | RP | Ari | 30 | April 19, 2025:60 Day IL-Left elbow inflammation |