| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Edgar Quero | C | ChA | 22 | |
| Freddie Freeman | 1B | LAD | 35 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Matt Mervis | 1B | Mia | 27 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Nick Gonzales | 2B | Pit | 25 | March 28, 2025:10 Day IL |
| Otto Lopez | 2B | Mia | 26 | |
| Willy Adames | SS | SF | 29 | |
| Anthony Volpe | SS | NYA | 24 | |
| Matt Chapman | 3B | SF | 32 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Brenton Doyle | OF | Col | 26 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Michael Harris II | OF | Atl | 24 | |
| Josh Lowe | OF | TB | 27 | March 29, 2025:10 Day IL |
| Bryan Reynolds | OF | Pit | 30 | |
| Colby Thomas | OF | Oak | 24 | |
| Daulton Varsho | OF | Tor | 28 | |
| Mike Yastrzemski | OF | SF | 34 | |
| Christian Yelich | OF | Mil | 33 | |
| Osvaldo Bido | SP | Oak | N/A | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Corbin Burnes | SP | Ari | 30 | |
| Tylor Megill | SP | NYN | 29 | |
| Reese Olson | SP | Det | 25 | |
| Freddy Peralta | SP | Mil | 28 | |
| Jose Quintana | SP | Mil | 36 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Kodai Senga | SP | NYN | 32 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Josh Hader | RP | Hou | 31 | |
| Devin Williams | RP | NYA | 30 |