| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Salvador Perez | C (C,1B) | KC | 34 | |
| Will Smith | C | LAD | 30 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Nick Gonzales | 2B | Pit | 25 | March 28, 2025:10 Day IL |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Ketel Marte | 2B | Ari | 31 | |
| Brendan Rodgers | 2B | Hou | 28 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Jacob Wilson | SS | Oak | 23 | |
| Alex Bregman | 3B | Bos | 31 | |
| Matt Vierling | 3B | Det | 28 | March 27, 2025:10 Day IL |
| Adolis Garcia | OF | Tex | 32 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Brent Rooker | OF | Oak | 30 | |
| George Springer | OF | Tor | 35 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Jordan Walker | OF | StL | 22 | |
| Marcell Ozuna | DH | Atl | 34 | |
| Shane Baz | SP | TB | 25 | |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Erick Fedde | SP | StL | 32 | |
| Bowden Francis | SP | Tor | 29 | |
| Merrill Kelly | SP | Ari | 36 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Reynaldo Lopez | SP | Atl | 31 | March 31, 2025:60 Day IL |
| Carlos Rodon | SP | NYA | 32 | |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Framber Valdez | SP | Hou | 31 | |
| Randy Vasquez | SP | SD | 26 | |
| Kyle Finnegan | RP | Was | 33 | |
| Trevor Megill | RP | Mil | 31 | |
| Ryan Pressly | RP | ChN | 36 |