| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Samuel Basallo | C | Bal | 20 | |
| J.T. Realmuto | C | Phi | 34 | |
| Keibert Ruiz | C | Was | 26 | |
| Bryce Eldridge | 1B | SF | 20 | |
| Matt Mervis | 1B | Mia | 27 | |
| Michael Toglia | 1B | Col | 26 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Matt McLain | 2B | Cin | 25 | |
| Bryson Stott | 2B | Phi | 27 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Elly De La Cruz | SS | Cin | 23 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Alec Bohm | 3B | Phi | 28 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Josh Jung | 3B | Tex | 27 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Randy Arozarena | OF | Sea | 30 | |
| Jordan Beck | OF | Col | 24 | |
| Riley Greene | OF | Det | 24 | |
| Juan Soto | OF | NYN | 26 | |
| Jose Berrios | SP | Tor | 30 | |
| Lucas Giolito | SP | Bos | 30 | |
| MacKenzie Gore | SP | Was | 26 | |
| Gunnar Hoglund | SP | Oak | 25 | |
| Jesus Luzardo | SP | Phi | 27 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Bryce Miller | SP | Sea | 26 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Robbie Ray | SP | SF | 33 | |
| Chris Sale | SP | Atl | 36 | |
| Cristopher Sanchez | SP | Phi | 28 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Carlos Estevez | RP | KC | 32 |