| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Yandy Diaz | 1B | TB | 33 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Anthony Volpe | SS | NYA | 24 | |
| Connor Norby | 3B | Mia | 24 | |
| Austin Riley | 3B | Atl | 28 | |
| Matt Shaw | 3B | ChN | 23 | |
| Byron Buxton | OF | Min | 31 | |
| Evan Carter | OF | Tex | 22 | |
| TJ Friedl | OF | Cin | 29 | |
| Cedric Mullins II | OF | Bal | 30 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Andy Pages | OF | LAD | 24 | |
| Heliot Ramos | OF | SF | 25 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Kyle Stowers | OF | Mia | 27 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Taj Bradley | SP | TB | 24 | |
| Hunter Brown | SP | Hou | 26 | |
| Corbin Burnes | SP | Ari | 30 | |
| Chase Dollander | SP | Col | N/A | |
| Tanner Houck | SP | Bos | 28 | |
| Matthew Liberatore | SP | StL | 25 | |
| Max Meyer | SP | Mia | 26 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Bryan Woo | SP | Sea | 25 | |
| Edwin Diaz | RP | NYN | 31 | |
| Kenley Jansen | RP | LAA | 37 | |
| Tanner Scott | RP | LAD | 30 |