| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Carson Kelly | C | ChN | 30 | |
| Adley Rutschman | C | Bal | 27 | |
| Willson Contreras | 1B | StL | 32 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Carlos Santana | 1B | Cle | 39 | |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Brandon Lowe | 2B | TB | 30 | |
| Tyler Freeman | SS (2B) | Col | 25 | April 13, 2025:10 Day IL |
| Geraldo Perdomo | SS | Ari | 25 | |
| Jose Tena | SS (3B) | Was | 24 | |
| Junior Caminero | 3B | TB | 21 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Luis Urias | 3B (2B) | Oak | 27 | |
| Jo Adell | OF | LAA | 26 | |
| Michael Conforto | OF | LAD | 32 | |
| Lourdes Gurriel | OF | Ari | 31 | |
| Anthony Santander | OF | Tor | 30 | |
| Matt Wallner | OF | Min | 27 | April 17, 2025:10 Day IL |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Cody Bradford | SP | Tex | 27 | |
| Alexander Cobb | SP | Det | 37 | March 27, 2025:15 Day IL |
| Jacob deGrom | SP | Tex | 36 | |
| Jackson Jobe | SP | Det | 22 | |
| Yusei Kikuchi | SP | LAA | 33 | |
| Bobby Miller | SP | LAD | 26 | |
| Nick Pivetta | SP | SD | 32 | |
| Paul Skenes | SP | Pit | 22 | |
| Gavin Williams | SP | Cle | 25 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Porter Hodge | RP | ChN | 24 | |
| Mason Miller | RP | Oak | 26 | |
| Andres Munoz | RP | Sea | 26 |