| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Gabriel Moreno | C | Ari | 25 | |
| Luis Arraez | 1B | SD | 28 | |
| Matt Olson | 1B | Atl | 31 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Marcus Semien | 2B | Tex | 34 | |
| Xavier Edwards | SS | Mia | 25 | |
| Jeremy Pena | SS | Hou | 27 | |
| Dansby Swanson | SS | ChN | 31 | |
| Masyn Winn | SS | StL | 23 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Jasson Dominguez | OF | NYA | 22 | |
| Michael Harris II | OF | Atl | 24 | |
| Steven Kwan | OF | Cle | 27 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Victor Scott | OF | StL | 24 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Daulton Varsho | OF | Tor | 28 | |
| Chris Bassitt | SP | Tor | 36 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Garrett Crochet | SP | Bos | 25 | |
| Sonny Gray | SP | StL | 35 | |
| Hunter Greene | SP | Cin | 25 | |
| Shota Imanaga | SP | ChN | 31 | |
| Pablo Lopez | SP | Min | 29 | |
| Bailey Ober | SP | Min | 29 | |
| Ryan Pepiot | SP | TB | 27 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Joe Ryan | SP | Min | 28 | |
| Shane Smith | SP | ChA | N/A | |
| Felix Bautista | RP | Bal | 29 | |
| Josh Hader | RP | Hou | 31 |