| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Cal Raleigh | C | Sea | 28 | |
| Tyler Stephenson | C | Cin | 28 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Brice Turang | 2B | Mil | 25 | |
| Willy Adames | SS | SF | 29 | |
| Ha-seong Kim | SS | TB | 29 | March 27, 2025:10 Day IL |
| Max Muncy | SS (2B) | Oak | 22 | |
| Zach Neto | SS | LAA | 24 | |
| Rafael Devers | 3B | Bos | 28 | |
| Josh Smith | 3B (SS,OF) | Tex | 27 | |
| Nick Castellanos | OF | Phi | 33 | |
| Aaron Judge | OF | NYA | 33 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Brayan Bello | SP | Bos | 25 | |
| Matt Boyd | SP | ChN | 34 | |
| Ben Brown | SP | ChN | 25 | |
| Bubba Chandler | SP | Pit | N/A | |
| Zac Gallen | SP | Ari | 29 | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Mitch Keller | SP | Pit | 29 | |
| Aaron Nola | SP | Phi | 31 | |
| Cole Ragans | SP | KC | 27 | |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Jameson Taillon | SP | ChN | 33 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |
| Shelby Miller | RP | Ari | 34 | |
| Will Vest | RP | Det | 29 |