| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Gabriel Moreno | C | Ari | 25 | |
| Sean Murphy | C | Atl | 30 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Edouard Julien | 2B | Min | 26 | |
| Matt McLain | 2B | Cin | 25 | |
| Mookie Betts | SS | LAD | 32 | |
| Gunnar Henderson | SS | Bal | 23 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jacob Wilson | SS | Oak | 23 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Mark Vientos | 3B | NYN | 25 | |
| Corbin Carroll | OF | Ari | 24 | |
| Jackson Chourio | OF | Mil | 21 | |
| Charlie Condon | OF | Col | 22 | |
| Michael Conforto | OF | LAD | 32 | |
| Walker Jenkins | OF | Min | 20 | |
| Wyatt Langford | OF | Tex | 23 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Kyle Tucker | OF | ChN | 28 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Tanner Bibee | SP | Cle | 26 | |
| Bubba Chandler | SP | Pit | N/A | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Nathan Eovaldi | SP | Tex | 35 | |
| Kevin Gausman | SP | Tor | 34 | |
| Clay Holmes | SP | NYN | 32 | |
| Clayton Kershaw | SP | LAD | 37 | March 27, 2025:15 Day IL-Ab strain |
| Michael King | SP | SD | 29 | |
| Ryan Pepiot | SP | TB | 27 | |
| Will Warren | SP | NYA | N/A | |
| Gavin Williams | SP | Cle | 25 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Shelby Miller | RP | Ari | 34 |