| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Austin Nola | C (DH) | SD | 30 | |
| Christian Vazquez | C (DH) | Bos | 30 | |
| Ji-Man Choi | 1B | TB | 29 | September 13, 2020:10 Day IL-Strained left hamstring |
| Dom Smith | 1B (OF,DH) | NYN | 25 | |
| Dan Vogelbach | 1B (DH) | Mil | 27 | |
| Jose Altuve | 2B | Hou | 30 | |
| Luis Arraez | 2B | Min | 23 | |
| Donovan Solano | 2B (3B) | SF | 32 | |
| Willy Adames | SS | TB | 25 | |
| Jorge Polanco | SS | Min | 27 | |
| Asdrubal Cabrera | 3B (1B,DH) | Was | 35 | |
| Manny Machado | 3B (DH) | SD | 28 | |
| Byron Buxton | OF | Min | 26 | |
| Kole Calhoun | OF (DH) | Ari | 33 | |
| Corey Dickerson | OF (DH) | Mia | 31 | |
| Sam Hilliard | OF | Col | 26 | |
| Victor Robles | OF | Was | 23 | |
| Nick Senzel | OF | Cin | 25 | |
| Austin Slater | OF (DH) | SF | 27 | |
| Ian Anderson | SP | Atl | 22 | |
| Jose Berrios | SP | Min | 26 | |
| Dylan Cease | SP | ChA | 24 | |
| Johnny Cueto | SP | SF | 34 | |
| Corey Kluber | SP | Tex | 34 | July 28, 2020:15 Day IL-Abdomen |
| Michael Kopech | SP | ChA | 24 | |
| Casey Mize | SP | Det | 23 | |
| Rafael Montero | SP (RP) | Tex | 29 | |
| Joe Musgrove | SP | Pit | 27 | |
| Carlos Rodon | SP (RP) | ChA | 27 | |
| Sixto Sánchez | SP | Mia | 22 | |
| Justus Sheffield | SP | Sea | 24 | |
| Julio Urías | SP | LAD | 24 | |
| Forrest Whitley | SP | Hou | 23 | |
| Daniel Hudson | RP | Was | 33 |