| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Carlos Narvaez | C | Bos | 26 | |
| Cal Raleigh | C | Sea | 28 | |
| Michael Busch | 1B | ChN | 27 | |
| Willson Contreras | 1B | StL | 33 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Jose Altuve | 2B (OF) | Hou | 35 | |
| Nolan Gorman | 2B (3B) | StL | 25 | |
| Zach McKinstry | 2B (SS,3B,OF) | Det | 30 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Gunnar Henderson | SS | Bal | 24 | |
| Manny Machado | 3B | SD | 32 | |
| Noelvi Marte | 3B | Cin | 23 | May 07, 2025:10 Day IL |
| Yoan Moncada | 3B | LAA | 30 | June 02, 2025:10 Day IL |
| Andrew Benintendi | OF | ChA | 30 | |
| Kerry Carpenter | OF | Det | 27 | |
| Trevor Larnach | OF | Min | 28 | |
| Ramón Laureano | OF | Bal | 30 | |
| Luis Robert Jr. | OF | ChA | 27 | June 29, 2025:10 Day IL |
| Mick Abel | SP | Phi | N/A | |
| Shane Bieber | SP | Cle | 30 | March 27, 2025:15 Day IL |
| Matt Boyd | SP | ChN | 34 | |
| Luis Castillo | SP | Sea | 32 | |
| Hunter Greene | SP | Cin | 25 | June 04, 2025:15 Day IL |
| Zack Littell | SP | TB | 29 | |
| Tyler Mahle | SP | Tex | 30 | June 15, 2025:15 Day IL |
| David Peterson | SP | NYN | 29 | |
| Jose Quintana | SP | Mil | 36 | |
| José Soriano | SP | LAA | 26 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Pete Fairbanks | RP | TB | 31 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Robert Suarez | RP | SD | 34 | |
| Will Vest | RP | Det | 30 |