| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Gabriel Moreno | C | Ari | 25 | |
| Sean Murphy | C | Atl | 30 | |
| Freddie Freeman | 1B | LAD | 35 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Christian Moore | 2B | LAA | 22 | |
| Mookie Betts | SS | LAD | 32 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jacob Wilson | SS | Oak | 23 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Rafael Devers | 3B | Bos | 28 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Roman Anthony | OF | Bos | 20 | |
| Jarren Duran | OF | Bos | 28 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| TJ Friedl | OF | Cin | 29 | |
| Walker Jenkins | OF | Min | 20 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Clay Holmes | SP | NYN | 32 | |
| Grant Holmes | SP | Atl | N/A | |
| Jackson Jobe | SP | Det | 22 | |
| Clayton Kershaw | SP | LAD | 37 | March 27, 2025:15 Day IL-Ab strain |
| Pablo Lopez | SP | Min | 29 | |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| Reese Olson | SP | Det | 25 | |
| Jose Quintana | SP | Mil | 36 | |
| Drew Rasmussen | SP | TB | 29 | |
| Kyle Finnegan | RP | Was | 33 | |
| Tanner Scott | RP | LAD | 30 |