| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | |
| Bo Naylor | C | Cle | 25 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Michael Busch | 1B | ChN | 27 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Brandon Lowe | 2B | TB | 30 | |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Xander Bogaerts | SS | SD | 32 | |
| Carlos Correa | SS | Min | 30 | |
| Colson Montgomery | SS | ChA | 23 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Jose Ramirez | 3B | Cle | 32 | |
| JJ Bleday | OF | Oak | 27 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Victor Robles | OF | Sea | 27 | April 07, 2025:60 Day IL |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Kyle Stowers | OF | Mia | 27 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Matt Boyd | SP | ChN | 34 | |
| Ben Brown | SP | ChN | 25 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Bowden Francis | SP | Tor | 29 | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Shota Imanaga | SP | ChN | 31 | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Nick Pivetta | SP | SD | 32 | |
| Roki Sasaki | SP | LAD | 23 | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Gavin Williams | SP | Cle | 25 | |
| David Bednar | RP | Pit | 30 | |
| Camilo Doval | RP | SF | 27 | |
| Kyle Finnegan | RP | Was | 33 | |
| Porter Hodge | RP | ChN | 24 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |