| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Carson Kelly | C | ChN | 30 | |
| Edgar Quero | C | ChA | 22 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Freddie Freeman | 1B | LAD | 35 | |
| Matt Olson | 1B | Atl | 31 | |
| Michael Toglia | 1B | Col | 26 | |
| Otto Lopez | 2B | Mia | 26 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| Trea Turner | SS | Phi | 31 | |
| Jacob Wilson | SS | Oak | 23 | |
| Josh Jung | 3B | Tex | 27 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Connor Norby | 3B | Mia | 24 | |
| Mark Vientos | 3B | NYN | 25 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Michael Harris II | OF | Atl | 24 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Luis Robert Jr. | OF | ChA | 27 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Daulton Varsho | OF | Tor | 28 | |
| Hunter Brown | SP | Hou | 26 | |
| Max Fried | SP | NYA | 31 | |
| Zac Gallen | SP | Ari | 29 | |
| Hunter Greene | SP | Cin | 25 | |
| Ryan Gusto | SP (RP) | Hou | N/A | |
| Nick Lodolo | SP | Cin | 27 | |
| Tylor Megill | SP | NYN | 29 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Cole Ragans | SP | KC | 27 | |
| José Soriano | SP | LAA | 26 | |
| Alexis Diaz | RP | Cin | 28 | |
| Luke Jackson | RP | Tex | 33 | |
| Kenley Jansen | RP | LAA | 37 |