| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ryan Jeffers | C | Min | 27 | |
| Agustin Ramirez | C | Mia | 23 | |
| Will Smith | C | LAD | 30 | |
| Deyvison De Los Santos | 1B | Mia | 21 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| J.P. Crawford | SS | Sea | 30 | |
| Anthony Volpe | SS | NYA | 24 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Noelvi Marte | 3B | Cin | 23 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Andrew Benintendi | OF | ChA | 30 | |
| Evan Carter | OF | Tex | 22 | |
| Dylan Crews | OF | Was | 23 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Michael Harris II | OF | Atl | 24 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Victor Scott | OF | StL | 24 | |
| Chandler Simpson | OF | TB | 24 | |
| Jordan Walker | OF | StL | 22 | |
| Andrew Abbott | SP | Cin | 25 | |
| Tyler Anderson | SP | LAA | 35 | |
| Max Fried | SP | NYA | 31 | |
| Jack Leiter | SP | Tex | N/A | |
| Max Meyer | SP | Mia | 26 | |
| Roki Sasaki | SP | LAD | 23 | |
| Justin Verlander | SP | SF | 42 | |
| Ryan Weathers | SP | Mia | 25 | March 27, 2025:15 Day IL |
| Bryan Woo | SP | Sea | 25 | |
| Carlos Estevez | RP | KC | 32 | |
| Luke Jackson | RP | Tex | 33 |