| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Logan O'Hoppe | C | LAA | 25 | |
| Will Smith | C | LAD | 30 | |
| Michael Busch | 1B | ChN | 27 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Marcus Semien | 2B | Tex | 34 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Ha-seong Kim | SS | TB | 29 | March 27, 2025:10 Day IL |
| Francisco Lindor | SS | NYN | 31 | |
| Edmundo Sosa | SS (2B) | Phi | 29 | |
| Alec Bohm | 3B | Phi | 28 | |
| Mark Vientos | 3B | NYN | 25 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Sal Frelick | OF | Mil | 25 | |
| Walker Jenkins | OF | Min | 20 | |
| Juan Soto | OF | NYN | 26 | |
| George Springer | OF | Tor | 35 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Kyle Tucker | OF | ChN | 28 | |
| Brayan Bello | SP | Bos | 25 | |
| Tanner Bibee | SP | Cle | 26 | |
| Hunter Greene | SP | Cin | 25 | |
| Mitch Keller | SP | Pit | 29 | |
| Clayton Kershaw | SP | LAD | 37 | March 27, 2025:15 Day IL-Ab strain |
| Yusei Kikuchi | SP | LAA | 33 | |
| Casey Mize | SP | Det | 28 | |
| Bailey Ober | SP | Min | 29 | |
| Framber Valdez | SP | Hou | 31 | |
| Randy Vasquez | SP | SD | 26 | |
| Pete Fairbanks | RP | TB | 31 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |
| Trevor Megill | RP | Mil | 31 |