| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Keibert Ruiz | C | Was | 26 | |
| Dalton Rushing | C | LAD | 24 | |
| Willson Contreras | 1B | StL | 32 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Wilmer Flores | 2B | SF | 33 | |
| Ketel Marte | 2B | Ari | 31 | |
| Thomas Saggese | 2B (SS) | StL | 23 | |
| Carlos Correa | SS | Min | 30 | |
| Anthony Volpe | SS | NYA | 24 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Junior Caminero | 3B | TB | 21 | |
| Austin Riley | 3B | Atl | 28 | |
| Ronald Acuna Jr. | OF | Atl | 27 | March 25, 2025:10 Day IL |
| Randy Arozarena | OF | Sea | 30 | |
| Evan Carter | OF | Tex | 22 | |
| Jackson Chourio | OF | Mil | 21 | |
| Oneil Cruz | OF | Pit | 26 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Christopher Morel | OF | TB | 25 | |
| Jose Berrios | SP | Tor | 30 | |
| Ronel Blanco | SP | Hou | 31 | |
| Matt Boyd | SP | ChN | 34 | |
| Bubba Chandler | SP | Pit | N/A | |
| Hunter Dobbins | SP | Bos | N/A | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Andrew Heaney | SP | Pit | 33 | |
| Matthew Liberatore | SP | StL | 25 | |
| Jacob Misiorowski | SP | Mil | N/A | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Edwin Diaz | RP | NYN | 31 | |
| Jhoan Duran | RP | Min | 27 | |
| Raisel Iglesias | RP | Atl | 35 | |
| Emilio Pagan | RP | Cin | 33 |