| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| Colt Keith | 1B (2B) | Det | 23 | |
| Christian Walker | 1B | Hou | 34 | |
| Nolan Gorman | 2B | StL | 24 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Brendan Rodgers | 2B | Hou | 28 | |
| Mookie Betts | SS | LAD | 32 | |
| Ha-seong Kim | SS | TB | 29 | March 27, 2025:10 Day IL |
| Jordan Lawlar | SS | Ari | 22 | |
| Manny Machado | 3B | SD | 32 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Isaac Paredes | 3B | Hou | 26 | |
| Sal Stewart | 3B | Cin | 21 | |
| Charlie Condon | OF | Col | 22 | |
| Michael Conforto | OF | LAD | 32 | |
| Oneil Cruz | OF | Pit | 26 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Jhonkensy Noel | OF | Cle | 23 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Jorge Soler | OF | LAA | 32 | |
| Matt Wallner | OF | Min | 27 | April 17, 2025:10 Day IL |
| Luis Castillo | SP | Sea | 32 | |
| Nick Lodolo | SP | Cin | 27 | |
| Freddy Peralta | SP | Mil | 28 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Cole Ragans | SP | KC | 27 | |
| Roki Sasaki | SP | LAD | 23 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Paul Skenes | SP | Pit | 22 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Justin Verlander | SP | SF | 42 | |
| Porter Hodge | RP | ChN | 24 | |
| Griffin Jax | RP | Min | 30 | |
| Andres Munoz | RP | Sea | 26 |