| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Keibert Ruiz | C | Was | 26 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Nolan Gorman | 2B | StL | 24 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| Gleyber Torres | 2B | Det | 28 | |
| Brice Turang | 2B | Mil | 25 | |
| Bo Bichette | SS | Tor | 27 | |
| J.P. Crawford | SS | Sea | 30 | |
| Max Muncy | 3B | LAD | 34 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Brenton Doyle | OF | Col | 26 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Brent Rooker | OF | Oak | 30 | |
| Anthony Santander | OF | Tor | 30 | |
| George Springer | OF | Tor | 35 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Nathan Eovaldi | SP | Tex | 35 | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Max Meyer | SP | Mia | 26 | |
| Bryce Miller | SP | Sea | 26 | |
| Casey Mize | SP | Det | 28 | |
| Andrew Painter | SP | Phi | N/A | |
| David Peterson | SP | NYN | 29 | |
| Carlos Rodon | SP | NYA | 32 | |
| Justin Verlander | SP | SF | 42 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Felix Bautista | RP | Bal | 29 | |
| David Bednar | RP | Pit | 30 | |
| Ryan Helsley | RP | StL | 30 | |
| Tanner Scott | RP | LAD | 30 |