| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| J.T. Realmuto | C | Phi | 34 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Kyle Manzardo | 1B | Cle | 24 | |
| Josh Naylor | 1B | Ari | 27 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Jeff McNeil | 2B | NYN | 33 | |
| Christian Moore | 2B | LAA | 22 | |
| Jeremy Pena | SS | Hou | 27 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Matt Shaw | 3B | ChN | 23 | |
| Miguel Vargas | 3B | ChA | 25 | |
| Lawrence Butler | OF | Oak | 24 | |
| Kerry Carpenter | OF | Det | 27 | |
| Dylan Crews | OF | Was | 23 | |
| Sal Frelick | OF | Mil | 25 | |
| Trent Grisham | OF | NYA | 28 | |
| Chandler Simpson | OF | TB | 24 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Alex Verdugo | OF | Atl | 28 | |
| Tyler Anderson | SP | LAA | 35 | |
| Kris Bubic | SP | KC | 27 | |
| Merrill Kelly | SP | Ari | 36 | |
| Zebby Matthews | SP | Min | N/A | |
| Tylor Megill | SP | NYN | 29 | |
| Reese Olson | SP | Det | 25 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Tarik Skubal | SP | Det | 28 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Michael Wacha | SP | KC | 33 | |
| Yoshinobu Yamamoto | SP | LAD | 26 |