| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Agustin Ramirez | C | Mia | 23 | |
| Austin Wells | C | NYA | 25 | |
| Luis Arraez | 1B | SD | 28 | |
| Jac Caglianone | 1B | KC | 22 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jacob Wilson | SS | Oak | 23 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Rafael Devers | 3B | Bos | 28 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Jordan Beck | OF | Col | 24 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Jesse Winker | OF | NYN | 31 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Garrett Crochet | SP | Bos | 25 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Tony Gonsolin | SP | LAD | 30 | |
| Gunnar Hoglund | SP | Oak | 25 | |
| Cade Horton | SP | ChN | 23 | |
| Jackson Jobe | SP | Det | 22 | |
| Jack Leiter | SP | Tex | N/A | |
| Gavin Williams | SP | Cle | 25 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Camilo Doval | RP | SF | 27 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |
| Mason Miller | RP | Oak | 26 |