| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | |
| Dillon Dingler | C | Det | N/A | |
| Tyler Stephenson | C | Cin | 28 | |
| Pete Alonso | 1B | NYN | 30 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Matt Mervis | 1B | Mia | 27 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Gleyber Torres | 2B | Det | 28 | |
| CJ Abrams | SS | Was | 24 | |
| Rafael Devers | 3B | Bos | 28 | |
| Ryan McMahon | 3B | Col | 30 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Mark Vientos | 3B | NYN | 25 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Corbin Carroll | OF | Ari | 24 | |
| Christopher Morel | OF | TB | 25 | |
| Juan Soto | OF | NYN | 26 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Zach Agnos | SP (RP) | Col | N/A | |
| Sandy Alcantara | SP | Mia | 29 | |
| Jose Berrios | SP | Tor | 30 | |
| Jackson Jobe | SP | Det | 22 | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Jack Leiter | SP | Tex | N/A | |
| Pablo Lopez | SP | Min | 29 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Casey Mize | SP | Det | 28 | |
| Reese Olson | SP | Det | 25 | |
| JP Sears | SP | Oak | 29 | |
| Jameson Taillon | SP | ChN | 33 | |
| Gavin Williams | SP | Cle | 25 | |
| David Bednar | RP | Pit | 30 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |