| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Pedro Pages | C | StL | 26 | |
| Agustin Ramirez | C | Mia | 23 | |
| J.T. Realmuto | C | Phi | 34 | |
| Triston Casas | 1B | Bos | 25 | |
| Ty France | 1B | Min | 30 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Brooks Lee | 2B (3B) | Min | 24 | |
| Matt McLain | 2B | Cin | 25 | |
| Enmanuel Valdez | 2B (1B) | Pit | 26 | |
| Bo Bichette | SS | Tor | 27 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Tyler Locklear | 3B | Sea | 24 | |
| Mark Vientos | 3B | NYN | 25 | |
| Jasson Dominguez | OF | NYA | 22 | |
| Jarren Duran | OF | Bos | 28 | |
| Trent Grisham | OF | NYA | 28 | |
| Walker Jenkins | OF | Min | 20 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Kameron Misner | OF | TB | N/A | |
| Cedric Mullins II | OF | Bal | 30 | |
| Andrew Abbott | SP | Cin | 25 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Max Fried | SP | NYA | 31 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Lucas Giolito | SP | Bos | 30 | |
| MacKenzie Gore | SP | Was | 26 | |
| Tanner Houck | SP | Bos | 28 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Bryan Woo | SP | Sea | 25 | |
| Carlos Estevez | RP | KC | 32 | |
| Jordan Romano | RP | Phi | 32 |