| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Cal Raleigh | C | Sea | 28 | |
| Jose Trevino | C | Cin | 32 | |
| Bryce Harper | 1B | Phi | 32 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Luis Garcia | 2B | Was | 24 | |
| Marcus Semien | 2B | Tex | 34 | |
| J.P. Crawford | SS | Sea | 30 | |
| Isiah Kiner-Falefa | SS | Pit | 30 | |
| Anthony Volpe | SS | NYA | 24 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Yoan Moncada | 3B | LAA | 29 | April 10, 2025:10 Day IL |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Matt Shaw | 3B | ChN | 23 | |
| Ben Williamson | 3B | Sea | N/A | |
| Cody Bellinger | OF | NYA | 29 | |
| Riley Greene | OF | Det | 24 | |
| Steven Kwan | OF | Cle | 27 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Jorge Soler | OF | LAA | 32 | |
| George Springer | OF | Tor | 35 | |
| Kyle Stowers | OF | Mia | 27 | |
| Ronel Blanco | SP | Hou | 31 | |
| Luis Castillo | SP | Sea | 32 | |
| Pat Corbin | SP | Tex | 35 | |
| Hunter Greene | SP | Cin | 25 | |
| Shota Imanaga | SP | ChN | 31 | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Tylor Megill | SP | NYN | 29 | |
| Andre Pallante | SP | StL | 26 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Jameson Taillon | SP | ChN | 33 | |
| Randy Vasquez | SP | SD | 26 | |
| Justin Verlander | SP | SF | 42 |