| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Yainer Diaz | C | Hou | 26 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Carlos Santana | 1B | Cle | 39 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Andrés Gimenez | 2B | Tor | 26 | |
| CJ Abrams | SS | Was | 24 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Mookie Betts | SS | LAD | 32 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Randy Arozarena | OF | Sea | 30 | |
| Corbin Carroll | OF | Ari | 24 | |
| Michael Harris II | OF | Atl | 24 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Kameron Misner | OF | TB | N/A | |
| Cedric Mullins II | OF | Bal | 30 | |
| Daulton Varsho | OF | Tor | 28 | |
| Alex Verdugo | OF | Atl | 28 | |
| Chris Bassitt | SP | Tor | 36 | |
| Taj Bradley | SP | TB | 24 | |
| Dylan Cease | SP | SD | 29 | |
| Tony Gonsolin | SP | LAD | 30 | |
| Sonny Gray | SP | StL | 35 | |
| Shota Imanaga | SP | ChN | 31 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Colin Rea | SP (RP) | ChN | 34 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Logan Webb | SP | SF | 28 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Jeff Hoffman | RP | Tor | 32 | |
| Kenley Jansen | RP | LAA | 37 |