| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Drake Baldwin | C | Atl | 24 | |
| Carson Kelly | C | ChN | 30 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Matt Olson | 1B | Atl | 31 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Michael Toglia | 1B | Col | 26 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Adael Amador | SS (2B) | Col | N/A | |
| Kyren Paris | SS (2B,OF) | LAA | 23 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Trea Turner | SS | Phi | 31 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Noelvi Marte | 3B | Cin | 23 | |
| Coby Mayo | 3B | Bal | 23 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Ronald Acuna Jr. | OF | Atl | 27 | March 25, 2025:10 Day IL |
| Yordan Alvarez | OF | Hou | 27 | |
| Kerry Carpenter | OF | Det | 27 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Andrew Heaney | SP | Pit | 33 | |
| Gunnar Hoglund | SP | Oak | 25 | |
| Matthew Liberatore | SP | StL | 25 | |
| Seth Lugo | SP | KC | 35 | |
| Tyler Mahle | SP | Tex | 30 | |
| Aaron Nola | SP | Phi | 31 | |
| Reese Olson | SP | Det | 25 | |
| Luis Ortiz | SP | Cle | 26 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Bryan Woo | SP | Sea | 25 | |
| Luke Jackson | RP | Tex | 33 | |
| Mason Miller | RP | Oak | 26 |