| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| J.T. Realmuto | C | Phi | 34 | |
| Jake Burger | 1B | Tex | 29 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Luis Garcia | 2B | Was | 24 | |
| Brandon Lowe | 2B | TB | 30 | |
| J.P. Crawford | SS | Sea | 30 | |
| Francisco Lindor | SS | NYN | 31 | |
| Logan Davidson | 3B | Oak | 27 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Mark Vientos | 3B | NYN | 25 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Brenton Doyle | OF | Col | 26 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Lars Nootbaar | OF | StL | 27 | |
| Andy Pages | OF | LAD | 24 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Ben Brown | SP | ChN | 25 | |
| Hunter Brown | SP | Hou | 26 | |
| Chase Burns | SP | Cin | 22 | |
| Luis Castillo | SP | Sea | 32 | |
| Zac Gallen | SP | Ari | 29 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Jack Leiter | SP | Tex | N/A | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Max Meyer | SP | Mia | 26 | |
| Mitchell Parker | SP | Was | 25 | |
| Joe Ryan | SP | Min | 28 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |