| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ryan Jeffers | C | Min | 27 | |
| Sean Murphy | C | Atl | 30 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Willson Contreras | 1B | StL | 32 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Nolan Gorman | 2B | StL | 24 | |
| Gabriel Arias | SS (2B,3B) | Cle | 25 | |
| Tyler Freeman | SS (2B) | Col | 25 | April 13, 2025:10 Day IL |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Michael Conforto | OF | LAD | 32 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Lourdes Gurriel | OF | Ari | 31 | |
| Trevor Larnach | OF | Min | 28 | |
| Anthony Santander | OF | Tor | 30 | |
| Jordan Walker | OF | StL | 22 | |
| Taylor Ward | OF | LAA | 31 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Tanner Bibee | SP | Cle | 26 | |
| Garrett Crochet | SP | Bos | 25 | |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Nick Pivetta | SP | SD | 32 | |
| Cole Ragans | SP | KC | 27 | |
| Kumar Rocker | SP | Tex | N/A | April 25, 2025:15 Day IL |
| Paul Skenes | SP | Pit | 22 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| David Bednar | RP | Pit | 30 | |
| Jason Foley | RP | Det | 29 | |
| Triston McKenzie | RP | Cle | 27 |