| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| J.T. Realmuto | C | Phi | 34 | |
| Will Smith | C | LAD | 30 | |
| Willson Contreras | 1B | StL | 32 | |
| Christian Walker | 1B | Hou | 34 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Matt McLain | 2B | Cin | 25 | |
| Willy Adames | SS | SF | 29 | |
| Jeremy Pena | SS | Hou | 27 | |
| Max Muncy | 3B | LAD | 34 | |
| Connor Norby | 3B | Mia | 24 | |
| Cody Bellinger | OF | NYA | 29 | |
| Evan Carter | OF | Tex | 22 | |
| Brenton Doyle | OF | Col | 26 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Brent Rooker | OF | Oak | 30 | |
| Chandler Simpson | OF | TB | 24 | |
| Colby Thomas | OF | Oak | 24 | |
| Daulton Varsho | OF | Tor | 28 | |
| Walker Buehler | SP | Bos | 30 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Jacob deGrom | SP | Tex | 36 | |
| Luis Gil | SP | NYA | 26 | March 24, 2025:60 Day IL |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Andrew Heaney | SP | Pit | 33 | |
| Zebby Matthews | SP | Min | N/A | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| JP Sears | SP | Oak | 29 | |
| José Soriano | SP | LAA | 26 | |
| Michael Wacha | SP | KC | 33 | |
| Simeon Woods Richardson | SP | Min | 24 | |
| José Alvarado | RP | Phi | 29 | |
| Camilo Doval | RP | SF | 27 | |
| Justin Martinez | RP | Ari | 23 | May 01, 2025:15 Day IL |