| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| Austin Wells | C | NYA | 25 | |
| Yandy Diaz | 1B | TB | 33 | |
| Freddie Freeman | 1B | LAD | 35 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Angel Martinez | 2B (OF) | Cle | 23 | |
| CJ Abrams | SS | Was | 24 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Xavier Edwards | SS | Mia | 25 | |
| Mark Vientos | 3B | NYN | 25 | |
| Ben Williamson | 3B | Sea | N/A | |
| Alex Call | OF | Was | 30 | |
| Jarren Duran | OF | Bos | 28 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Trevor Larnach | OF | Min | 28 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Seiya Suzuki | OF | ChN | 30 | |
| Jose Berrios | SP | Tor | 30 | |
| Hunter Dobbins | SP | Bos | N/A | |
| Jordan Hicks | SP | SF | 28 | |
| Shota Imanaga | SP | ChN | 31 | |
| Jake Irvin | SP | Was | 28 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Bryce Miller | SP | Sea | 26 | |
| Casey Mize | SP | Det | 28 | |
| Andre Pallante | SP | StL | 26 | |
| Landen Roupp | SP | SF | N/A | |
| Kodai Senga | SP | NYN | 32 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Trevor Williams | SP | Was | 33 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Pete Fairbanks | RP | TB | 31 | |
| Tommy Kahnle | RP | Det | 35 |