| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Yainer Diaz | C | Hou | 26 | |
| Luis Arraez | 1B | SD | 28 | |
| Eric Wagaman | 1B (OF) | Mia | N/A | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Wilmer Flores | 2B | SF | 33 | |
| Gleyber Torres | 2B | Det | 28 | |
| Elly De La Cruz | SS | Cin | 23 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Kerry Carpenter | OF | Det | 27 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Heston Kjerstad | OF | Bal | 26 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Cedric Mullins II | OF | Bal | 30 | |
| Victor Scott | OF | StL | 24 | |
| Matt Wallner | OF | Min | 27 | April 17, 2025:10 Day IL |
| Eli White | OF | Atl | 30 | |
| Taj Bradley | SP | TB | 24 | |
| Griffin Canning | SP | NYN | 28 | |
| Erick Fedde | SP | StL | 32 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Aaron Nola | SP | Phi | 31 | |
| Ryan Pepiot | SP | TB | 27 | |
| Chris Sale | SP | Atl | 36 | |
| Paul Skenes | SP | Pit | 22 | |
| Tarik Skubal | SP | Det | 28 | |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Edwin Diaz | RP | NYN | 31 | |
| Josh Hader | RP | Hou | 31 | |
| Emilio Pagan | RP | Cin | 33 | |
| Dennis Santana | RP | Pit | 29 | |
| Will Vest | RP | Det | 29 |