| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Sean Murphy | C | Atl | 30 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Hyeseong Kim | 2B | LAD | 26 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Marcus Semien | 2B | Tex | 34 | |
| Gunnar Henderson | SS | Bal | 23 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Rafael Devers | 3B | Bos | 28 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Lawrence Butler | OF | Oak | 24 | |
| Michael Harris II | OF | Atl | 24 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Tanner Bibee | SP | Cle | 26 | |
| Shane Bieber | SP | Cle | 29 | March 27, 2025:15 Day IL |
| Ronel Blanco | SP | Hou | 31 | |
| Bubba Chandler | SP | Pit | N/A | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Clay Holmes | SP | NYN | 32 | |
| Michael King | SP | SD | 29 | |
| Bailey Ober | SP | Min | 29 | |
| Robbie Ray | SP | SF | 33 | |
| Gavin Williams | SP | Cle | 25 | |
| Jeff Hoffman | RP | Tor | 32 | |
| Andres Munoz | RP | Sea | 26 |